Outcomes of a brand new multicenter examine revealed within the New England Journal of Drugs discovered that vaccination with a major sequence of the Pfizer-BioNTech mRNA COVID-19 vaccine decreased the danger of COVID-19-associated hospitalizations in kids ages 5–11 years by two-thirds in the course of the Omicron interval.
Amongst adolescents ages 12–18 years who had been vaccinated with a major sequence of Pfizer-BioNTech vaccine, safety towards COVID-19-associated hospitalization in the course of the Omicron interval was decrease than in the course of the Delta interval, much like what has been beforehand proven amongst adults. Ranges of safety towards important COVID-19 requiring life-supporting interventions remained excessive in vaccinated adolescents throughout each the Delta and the Omicron intervals.
Our examine outcomes are reassuring that COVID-19 vaccination in eligible kids and adolescents continues to guard towards essentially the most extreme outcomes related to COVID-19, no matter variant kind. It’s troublesome to foretell whether or not the vaccine can be as efficient towards the present subvariant of Omicron, however almost certainly the extent of safety can be comparable. Our outcomes reinforce the significance of COVID-19 vaccination, together with receiving a booster dose for these ages 12 years and older, to guard towards important sickness.”
Bria Coates, MD, Examine Co-Creator and Essential Care Doctor, Ann & Robert H. Lurie Kids’s Hospital of Chicago
Coates can be an Assistant Professor of Pediatrics at Northwestern College Feinberg College of Drugs
Throughout the Omicron interval (December 19, 2021–February 17, 2022), vaccination decreased the danger of COVID-19-associated hospitalization by 68 p.c in kids ages 5–11 years. Vaccine effectiveness towards any kind of COVID-19-associated hospitalization in adolescents ages 12–18 years who obtained a major sequence declined from 92 p.c in the course of the Delta (July 1, 2021–December 18, 2021) interval to 40 p.c in the course of the Omicron interval. Safety towards COVID-19 requiring life-supporting interventions remained excessive for adolescents throughout Delta (96 p.c) and Omicron (79 p.c).
Because of the low numbers of hospitalized kids ages 5–11 years within the examine, researchers couldn’t analyze vaccine effectiveness by illness severity for this age group however will proceed to watch as these information are collected. Information on this age group was not out there for the Delta interval, since youthful kids weren’t eligible for the vaccine at the moment.
Safety towards hospitalization in adolescents in the course of the Delta interval remained constant for greater than 6 months after receipt of a major sequence. Ranges of safety throughout Omicron, though decrease, additionally stayed constant over time after finishing the first sequence.
“This consistency in vaccine effectiveness throughout every variant means that the decline in safety amongst adolescents between the Delta and Omicron intervals is likely to be as a result of the Omicron variant is extra more likely to escape management by the immune system, moderately than waning immunity since vaccination,” mentioned Dr. Coates, who is also the Crown Household Analysis Scholar in Developmental Biology. “Nevertheless, extra information are wanted to reply this query.”